Modeling a macrocyclic bis[spirodiepoxide] strategy to erythronolide A.
نویسندگان
چکیده
A concise route to functionalized 14-membered macrolides related to erythronolide A was achieved. Key steps include the simultaneous formation of bis[allenic] substrates, efficient macrolactonization, highly stereoselective oxidation to the corresponding bis[spirodiepoxide], and nucleophilic spirodiepoxide opening. The structure and reactivity of these macrolides, and the strategy that led to their evaluation, are discussed.
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ورودعنوان ژورنال:
- Organic letters
دوره 11 19 شماره
صفحات -
تاریخ انتشار 2009